Targeted Next-generation Sequencing for Respiratory Infection Pathogen

Targeted Next-generation Sequencing for Respiratory Infection Pathogen

Targeted Next-generation Sequencing (tNGS) for Respiratory Infection Pathogen is an advanced clinical diagnostic sequencing technology based on targeted capture and multiplex PCR enrichment. It achieves rapid, comprehensive and accurate detection of respiratory infection pathogens by enriching the genome of specific pathogenic microbes before high-throughput sequencing and database comparison, providing a powerful molecular diagnostic tool for the clinical diagnosis and precise medication of respiratory infectious diseases.

Core Product Advantages

  1. Comprehensive Detection Coverage

    Covers all common respiratory tract infection pathogens including bacteria, fungi, DNA/RNA viruses, mycobacterium tuberculosis and special pathogens, and simultaneously detects antimicrobial resistance genes. Realizes one-step simultaneous detection of DNA and RNA, without separate testing, fully meeting the clinical needs of comprehensive pathogen screening.

  2. Ultra-Fast Detection Speed

    Powered by the self-propelled sequencing platform, the whole detection process from receiving qualified samples to issuing the test report only takes 8 hours (bitseq mode), realizing ultra-rapid pathogen diagnosis and winning precious time for clinical emergency treatment of critical patients.

  3. Wide Sample Compatibility

    Applicable to a variety of clinical common sample types such as bronchoalveolar lavage fluid, sputum and throat swabs, with flexible and convenient sample collection and detection, adapting to different clinical testing scenarios of respiratory infections.

  4. Economical and Reliable Detection

    Only detects specific amplified pathogen fragments, which greatly reduces the time and cost of the assay. Meanwhile, the targeted enrichment technology improves the stability and reproducibility of data processing results, ensuring the accuracy and reliability of detection results with high cost performance.

Applicable Population

  1. High-risk groups of acute upper respiratory tract infection
  2. Patients with lower respiratory tract infection, especially critical cases and those with poor previous treatment effect
  3. Patients with suspected tuberculosis infection
  4. Patients with chronic respiratory tract infection
  5. Immunosuppressed patients complicated with respiratory tract infection

Clinical Significance

  1. Accurately Locate Complex Infection Causes

    Effectively increases the detection rate of mixed and complex respiratory infections, accurately identifying the pathogenic spectrum of infected patients and providing a clear etiological basis for clinical etiological diagnosis.

  2. Detect Rare Pathogenic Species

    Enables sensitive detection of clinical rare respiratory infection pathogens, assisting in the diagnosis of rare and difficult respiratory infectious diseases and avoiding misdiagnosis and missed diagnosis.

  3. Guide Clinical Precise Medication

    Simultaneously detects antimicrobial resistance genes of pathogens, clarifying the drug resistance profile of infectious pathogens and providing scientific and precise guidance for clinical rational antibiotic selection and medication plan formulation.

  4. Improve Detection Accuracy of Difficult Pathogens

    Greatly increases the detection rate of traditional detection methods for difficult-to-detect respiratory pathogens, significantly improving the overall accuracy of respiratory infection pathogen diagnosis and optimizing clinical treatment decisions.

Standard Detection Process

  1. DNA/RNA co-extraction from clinical samples
  2. Targeted pathogen genome library construction via multiplex PCR
  3. High-throughput targeted sequencing on self-propelled platform
  4. Professional bioinformatics data analysis and database comparison
  5. Rapid compilation and release of clinical test report

Rapid Lead Time

Supports ultra-rapid detection and reporting, with the whole process from receiving qualified clinical samples to issuing the test report completed in 8 hours (bitseq mode), ensuring the timeliness of clinical etiological diagnosis and emergency treatment.

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