Optical coherence tomography (OCT) is a high-resolution, non-invasive imaging technology that can produce “super-resolution” images of the eye—without surgery or radiation.  In just a few seconds, it can create high-definition “cross-sectional images” of eye structures, even finer than the thickness of a human hair. This technology is particularly important in ophthalmology, allowing doctors to visualize every layer of the retina, detect early signs of macular degeneration, glaucoma, and other diseases, and even identify eye problems related to diabetes. However, when scientists study eye diseases using small animals like mice, they find that the structure of their eyes differs from that of human eyes.  The eye axis length, pupil size, and other parameters vary, making it difficult for standard OCT devices to produce clear images of the animal retina.